TOPICS COVERED
Medical Biostatistics, Fourth Edition
Chapman&Hall/CRC Press, 2018
____________A. Indrayan___________
Coverage of wide-ranging topics
“Probably the most complete book on Biostatistics”
CLINICAL EPIDEMIOLOGY
Probability in diagnosis
Bayes’ rule
Normal clinical values
Disease screening
Evaluation of diagnostic tests
ROC Curve
Clinimetrics
Evidence-based medicine
Assessment of agreement
Scoring systems
Meta analysis
CATEGORICAL DATA
Binomial distribution
Poisson distribution
Capture-recapture method
Contingency table
Goodness-of-fit tests
Exact tests
Ordinal data
Partition of chi-square
Polytomous data
Multinomial test
Measures of association
Cochran Q
Logistic regression
Log-linear models
Cox regression
Classification and regression trees
EPIDEMIOLOGICAL STUDIES
Prospective and cohort studies
Retrospective and case-control studies
Cross-sectional analytical studies
Comparative features
Biases
Confounding
Relative risk
Odds ratio
Population attributable risk
Mentel-Haenszel procedure
STROBE
CLINICAL TRIALS
Phases of clinical trials
Randomization and matching
Randomized controlled trials
Blinding and masking
Equivalence trials
Noninferiority margin
Therapeutic trials
Diagnostic trials
Screening trials
Prophylactic trials
Vaccine trials
Field trials
Crossover design
Up-and-down design
Intention-to-treat analysis
Adaptive designs and stopping rules
Sample size reestimation
CONSORT
DESIGNS OF EXPERIMENTS
Principles of experimentation
Animal and laboratory experiments
One-way and two-way designs
Interaction
Factorial designs
Unbalanced designs
Partially factorial designs
Repeated measures designs
Crossover and N-of-1 designs
MEDICAL RESEARCH
Protocol content
Critique of a medical write-up
Types of research designs
Tools of data collection
Pretesting and pilot study
Nonresponse and biases
Levels of evidence
SAMPLE SURVEYS
Sample size
Sampling terms
Methods of random sampling
Methods of nonrandom sampling
Choosing a sample design
DATA REPRESENTATION—NUMERICAL
Nominal, ordinal and metric scales
Frequency distribution
Gaussian and other patterns
Skewness
Statistical tables
Multiple-response
Proportion, rate and ratio
Mean, median and mode
Percentiles and quartiles
Standard deviation and coefficient of variation
DATA REPRESENTATION—GRAPHICAL
Histogram, polygon, and curve
Pie, bar, scatter, and line diagrams
Radar graph
Charts and maps
Growth charts
Epidemic curve
Dendrogram
STATISTICAL ANALYSIS
Confidence intervals
P-values and power
Sample size determination
Statistical significance
Medical significance
Student’s t-test
Analysis of variance (ANOVA)
Analysis of repeated measures
Analysis of covariance
Simple and multiple regression
Various types of correlations
Nonparametric methods
MEDICAL UNCERTAINTIES
Aleatory and epistemic uncertainties
Intrinsic variation
Variation in assessment
Inadequate knowledge
MULTIVARIATE METHODS
Multivariate analysis of variance (MANOVA)
Multivariate regression
Cluster analysis
Factor analysis
Discriminant analysis
Path analysis
SURVIVAL ANALYSIS
Censored data
Life expectancy
Life table analysis
Kaplan-Meier methods
Log-rank test
Proportional hazards
Cox model
STATISTICAL QUALITY IN MEDICINE
Quality control of medical care errors
Quality control in medical laboratory
Quality of measurements
Validity and reliability
Robustness
External validation
Sensitivity analysis
Uncertainty analysis
Bootstrap and Jackknifing
STATISTICAL FALLACIES
Biased sample
Incomparable groups
Mixing of groups
Misuse of percentages and means
Inappropriate reporting
Inadequate analysis
Misinterpretation
PUBLIC HEALTH
Standardized death rate
Standardized mortality ratio
Death spectrum
Prevalence and incidence
Attack rates
Epidemiological consistency
Dietary indices
Indicators of mental and social health
Disability-adjusted life years (DALYs)
Healthy life expectancy
Health situation analysis
Human development index